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fatigue life 10

fatigue 8

influence factor 4

influencing factor 4

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aircraft structure 3

microstructure 3

B p65 (NF-κ 2

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The Analyzing Method for Fatigue Life of Aircraft Structures Under Corrosive Environment

Mu Zhitao

Strategic Study of CAE 2002, Volume 4, Issue 3,   Pages 68-72

Abstract: the environment characteristics and corrosion depth distribution law of the naval aircraft structures fatiguenotch factor (Kf) and fatigue life mathematical model was built by using the Stress Fieldtaking into consideration the influences of corrosion depth in the ground environment and corrosion fatigueenvironment of the humidity air, salt fog, salt fog + SO2 this method made correction for fatigueFinally, combing with a real case of fatigue life and residual life prediction of the flange for the

Keywords： aircraft structure     fatigue life     corrosive environment     fatigue notch factor    

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Parametric equations for notch stress concentration factors of rib–deck welds under bending loading

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 3,   Pages 595-608 doi: 10.1007/s11709-021-0720-1

Abstract: The effective notch stress approach for evaluating the fatigue strength of rib–deck welds requires notchTo improve the efficiency of the approach, the notch stress concentration factors for three typical fatigue-crackingFirst, we developed a model for investigating the effective notch stress in rib–deck welds.The notch stress concentration factors estimated from the developed formulas show agree well with theIt also shows that the fatigue design curve of FAT225 seems to be conservative for evaluating the fatigue

Keywords： notch stress concentration factor     rib–deck weld     parametric analysis     regression analysis     parametric    

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Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 442-458 doi: 10.1007/s11684-021-0877-y

Abstract: More than 60% of T-ALL patients carry NOTCH1 gene mutations, leading to abnormal expression ofHDAC inhibitor, exerts an antitumor effect on T-ALL cell lines and primary cells including an anti-NOTCH1In particular, chidamide inhibits the NOTCH1-MYC signaling axis by down-regulating the level of the intracellularform of NOTCH1 (NICD1) as well as MYC, partly through their ubiquitination and degradation by the proteasomethe effectiveness and safety of chidamide in the treatment of T-ALL patients, including those with NOTCH1

Keywords： T-cell acute lymphoblastic leukemia     HDAC inhibitor     chidamide     NOTCH1     MYC     ubiquitination    

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Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

Muhammad Waqas,Shasha Zhang,Zuhong He,Mingliang Tang,Renjie Chai

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 237-249 doi: 10.1007/s11684-016-0464-9

Abstract: regenerative capacity because of the active participation of various signaling pathways, including Wnt and NotchThe Wnt and Notch pathways are highly sophisticated and conserved signaling pathways that control multipleIn this regard, Wnt and Notch signaling has gained increased research attention in hair cell regenerationThis review presents the current understanding of the Wnt and Notch signaling pathways in the auditory

Keywords： inner ear     cochlea     hair cell     regeneration     Wnt     Notch     signaling pathways    

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Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 705-712 doi: 10.1007/s11684-019-0703-y

Abstract: Wnt and Notch signaling play crucial roles in the determination of the prosensory domain and in the differentiationHere, we investigated the interactions between Notch and Wnt signaling on the basis of the bidirectionalregulation of Notch1 specifically in Wnt-responsive Lgr5 progenitors during different cochlear developmentWe found that the downregulation of Notch1 in Lgr5 cells from embryonic day (E) 14.5 to E18.5 can driveOur findings improved the understanding of the interactions between Notch and Wnt signaling in cochlear

Keywords： inner ear     cochlear     Wnt     Notch     Lgr5     auditory system    

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Crack propagation with different radius local random damage based on peridynamic theory

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 5,   Pages 1238-1248 doi: 10.1007/s11709-021-0695-y

Abstract: This study implements the peridynamic theory by subjecting bilateral notch cracked specimens to the conditions

Keywords： peridynamics     stochastic damage     bilateral notch crack    

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A dimensional analysis on asphalt binder fracture and fatigue cracking

Qian ZHAO, Zhoujing YE

Frontiers of Structural and Civil Engineering 2018, Volume 12, Issue 2,   Pages 201-206 doi: 10.1007/s11709-017-0402-1

Abstract: Fracture and fatigue cracking in asphalt binder are two of most serious problems for pavement engineersTheorem and -integral analysis based on classic fracture mechanics, to evaluate the fracture and fatiguediscovered that the dimensional analysis could provide a new perspective to analyze the asphalt fracture and fatigue

Keywords： Dimensional analysis     asphalt     fracture     fatigue cracking    

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Regeneration of hair cells in the mammalian vestibular system

Wenyan Li,Dan You,Yan Chen,Renjie Chai,Huawei Li

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 143-151 doi: 10.1007/s11684-016-0451-1

Abstract: regeneration and subsequent functional recovery of the vestibular system, including manipulating the Wnt, Notch

Keywords： utricle     hair cell     regeneration     Atoh1     Notch     Wnt    

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Hierarchical approach for fatigue cracking performance evaluation in asphalt pavements

Ibrahim ONIFADE, Yared DINEGDAE, Björn BIRGISSON

Frontiers of Structural and Civil Engineering 2017, Volume 11, Issue 3,   Pages 257-269 doi: 10.1007/s11709-017-0410-1

Abstract: In this paper, a hierarchical approach is proposed for the evaluation of fatigue cracking in asphaltThe levels of fatigue damage analysis provides pavement engineers a variety of tools that can be used

Keywords： fatigue cracking     energy based     crack initiation     mechanistic approach     pavement analysis    

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Assessment of fatigue life of remanufactured impeller based on FEA

Lei XU,Huajun CAO,Hailong LIU,Yubo ZHANG

Frontiers of Mechanical Engineering 2016, Volume 11, Issue 3,   Pages 219-226 doi: 10.1007/s11465-016-0394-x

Abstract:

Predicting the fatigue life of remanufactured centrifugal compressor impellers is a critical problemA fatigue life simulation model was built, and fatigue life was analyzed based on the fatigue cumulativelife impact factors and fatigue fracture areas.Results showed that the load amplitude greatly affected fatigue life, the impeller was protected fromrunning at over-speed, and the predicted fatigue life was satisfied within the next service cycle safely

Keywords： remanufactured impeller     fatigue life     impeller failures     finite element analysis (FEA)    

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Study on fatigue performance of steel deck pavement for the Fourth Nanjing Yangtze River Bridge

Zhan Yu,Li Guofen,Wang Hongchang

Strategic Study of CAE 2013, Volume 15, Issue 8,   Pages 75-78

Abstract: Based on the steel deck pavement of the Fourth Nanjing Yangtze River Bridge, this paper carried out fatigueThe splitting fatigue tests and five stress levels of 0.2, 0.3, 0.4, 0.5, 0.6 were used to study thefatigue property of each layer; in dition, the fatigue tests of composite beams with steel plates andthree load levels of 6 kN, 7 kN, 8 kN were chosen to study the fatigue property of the composite structureFinally, the fatigue equation by regression analysis was got.

Keywords： highway engineering     steel deck pavement     fatigue property     splitting fatigue     fatigue equation    

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Contact fatigue life prediction of a bevel gear under spectrum loading

Pan JIA, Huaiju LIU, Caichao ZHU, Wei WU, Guocheng LU

Frontiers of Mechanical Engineering 2020, Volume 15, Issue 1,   Pages 123-132 doi: 10.1007/s11465-019-0556-8

Abstract: Rolling contact fatigue (RCF) issues, such as pitting, might occur on bevel gears because load fluctuationsimulated with the finite element method, and the RCF life is predicted using the Brown–Miller–Morrow fatigueThe patterns of fatigue life on the tooth surface are simulated under various loading levels, and theThe effects of various fatigue damage accumulation rules on fatigue life are compared and discussed in

Keywords： bevel gear     rolling contact fatigue (RCF)     multiaxial fatigue criterion     load spectrum     damage accumulation    

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Enhancing fatigue life of cylinder-crown integrated structure by optimizing dimension

Weiwei ZHANG,Xiaosong WANG,Zhongren WANG,Shijian YUAN

Frontiers of Mechanical Engineering 2015, Volume 10, Issue 1,   Pages 102-110 doi: 10.1007/s11465-015-0329-y

Abstract: During the engineering design of cylinder-crown integrated structure, in order to increase the fatigueSubsequently, strain-controlled fatigue test is carried out, and the stress-strain hysteresis loops andBased on linear fit, the fatigue properties are calculated and used for the fatigue life prediction.It is shown that the predicted fatigue life is significantly increased from 157000 to 1070000 cycles

Keywords： cylinder-crown integrated hydraulic press (CCIHP)     adaptive macro genetic algorithms (AMGA)     strain-controlled fatigue    

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Investigation of fatigue resistance of fillet-welded tube connection details for sign support structures

Hyungjoo CHOI, Husam NAJM

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 1,   Pages 199-214 doi: 10.1007/s11709-019-0592-9

Abstract: results and the variability in existing fatigue testing results.The resulting fatigue resistance from FE analysis was expressed in terms of fatigue life, fatigue damage, and fatigue safety factor to determine the fatigue performance of fillet-welded connections.provided to determine input data and fatigue limit for the fatigue module.the form of fatigue life, fatigue damage and safety factor for various connection parameters and structural

Keywords： fatigue     weld connections     base plate     fillet welds    

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The Corrosion Fatigue and Life of Aircraft Structure in Servicing

Mu Zhitao,Jin Ping,Duan Chengmei

Strategic Study of CAE 2000, Volume 2, Issue 4,   Pages 34-38

Abstract: method of establishing environmental spectrum for airport and the calculating methods of corrosion fatigueSome views for the research and development on corrosion fatigue of warplane in the future were put forward

Keywords： corrosion     aircraft structure     corrosion fatigue     fatigue life     corrosion environmental spectrum    

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Title Author Date Type Operation

The Analyzing Method for Fatigue Life of Aircraft Structures Under Corrosive Environment

Mu Zhitao

Journal Article

Parametric equations for notch stress concentration factors of rib–deck welds under bending loading

Journal Article

Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Journal Article

Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

Muhammad Waqas,Shasha Zhang,Zuhong He,Mingliang Tang,Renjie Chai

Journal Article

Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

Journal Article

Crack propagation with different radius local random damage based on peridynamic theory

Journal Article

A dimensional analysis on asphalt binder fracture and fatigue cracking

Qian ZHAO, Zhoujing YE

Journal Article

Regeneration of hair cells in the mammalian vestibular system

Wenyan Li,Dan You,Yan Chen,Renjie Chai,Huawei Li

Journal Article

Hierarchical approach for fatigue cracking performance evaluation in asphalt pavements

Ibrahim ONIFADE, Yared DINEGDAE, Björn BIRGISSON

Journal Article

Assessment of fatigue life of remanufactured impeller based on FEA

Lei XU,Huajun CAO,Hailong LIU,Yubo ZHANG

Journal Article

Study on fatigue performance of steel deck pavement for the Fourth Nanjing Yangtze River Bridge

Zhan Yu,Li Guofen,Wang Hongchang

Journal Article

Contact fatigue life prediction of a bevel gear under spectrum loading

Pan JIA, Huaiju LIU, Caichao ZHU, Wei WU, Guocheng LU

Journal Article

Enhancing fatigue life of cylinder-crown integrated structure by optimizing dimension

Weiwei ZHANG,Xiaosong WANG,Zhongren WANG,Shijian YUAN

Journal Article

Investigation of fatigue resistance of fillet-welded tube connection details for sign support structures

Hyungjoo CHOI, Husam NAJM

Journal Article

The Corrosion Fatigue and Life of Aircraft Structure in Servicing

Mu Zhitao,Jin Ping,Duan Chengmei

Journal Article